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Analysis Of the Physiological Function Of Renal Tubules

This article was provided by doctor zhengfalei 2018-06-24 10:11

When an old patient actually had nocturnal enuresis and anemia , but at the time he only thought it was because of age. Instead, they have taken care of coronary heart disease for more than a decade and have taken Guanxin Pills all year round. Due to the increasing severity of anaemia, nocturia increased 5-6 times per night, and the spirit was poor and the diet was not good. It was diagnosed as drug-induced renal tubular interstitial nephritis, creatinine 500 umol/L, kidney atrophy, and complications such as anemia, hypertension, and electrolyte imbalance. The treatment of traditional Chinese medicine and Western medicine has not been interrupted for one year, but kidney disease has not improved for the first time, but it has gradually deteriorated. The illness made me feel bad and I had no hope for life. Just as I was desperate, I was introduced by a friend and I came to the Beijing Tongshantang Hospital of Traditional Chinese Medicine to accept the systemic natural treatment network for kidney disease. Just after entering the hospital, my creatinine began to decreaseose to the low level in normal range. the urine specific gravity in the morning urine was 1.015, and the 24-hour potassium, sodium, and chloride excretion values ​​were all improved. When the diagnosis came out, I was totally couraged and full of confidence for the next treatment.

What are the physiological functions of the renal tubules

“The physiological function of the renal tubules.” Well, it is actually achieved by the renal tubular epithelial cells. It firstly absorbs the water, electrolytes and nutrients in the raw urine, such as glucose and amino acids, and transports the substances from the renal tubules to the blood. Followed by the secretion of H +, K + and organic matter, excretion of wastes such as urea and organic acids, that is, the substances produced by the epithelial cells themselves or blood substances are transported to the lumen of the renal tubules. In addition, urine concentration and dilution are important physiological functions of the renal tubules. ”

Is urine specific gravity the only way to determine the concentration and dilution of renal tubules? Concentration and dilution of urine mainly refers to the concentration of various substances in the urine, and its function is mainly performed in the distal tubule and the collecting tubule. The formation of medullary osmotic pressure gradient, hyperosmolar state, function of epithelial cells in distal tubules and collecting tubules, and secretion of antidiuretic hormones all play a decisive role in the function of the renal tubules to concentrate and dilute urine. To determine the concentration and dilution of renal tubules, in addition to looking at the urine specific gravity, we can also see changes in urine osmotic pressure. Urinary osmotic pressure (also known as urine infiltration) is the number of particles that reflect solute molecules and ions in a unit volume of urine. It is only related to the concentration of solute molecules, and is not affected by the molecular weight of solute. .

What is the relationship between the damage of the renal tubules and the nocturia and anemia? What are the common symptoms after it is damaged?

The reason why there is nocturia and anemia is because: The glomerulus filters about 19% of the blood in the arterioles into the renal tubules to form the original urine. The renal tubules also use about 99% of the original urine to help the human body, such as the vast majority of water, all glucose, Some of the inorganic salts are reabsorbed and returned to the blood in the capillaries surrounding the renal tubules. The original urine is reabsorbed by the renal tubules. The remaining water, inorganic salts, urea, and uric acid form urine. Once the physiological function of the renal tubule is impaired, the original balance between the renal tubule, glomerulus, and blood will be broken. In this way, the metabolic waste in the blood cannot be completely discharged and the relative stability of the blood volume is also challenged.

Of course, when people fall asleep at night, the metabolism is relatively slowed down, and the amount of blood needed for other tissues and organs is reduced accordingly, so the amount of blood flowing through the kidney into the arterioles increases. At this time, if there is a problem with the physiological function of the renal tubules, it affects the absorption of the original urine, increases the amount of final urine formation, and the phenomenon of increased urination at night occurs. As for the anemia phenomenon, it is because the renal tubules are in the middle of the renal interstitium, and they often develop together. The interstitial fibroblasts have the task of secreting erythropoietin, and the fibroblasts undergo pathological changes, and the task of secreting erythropoietin cannot be performed normally, thus leading to renal anemia. Anemia in patients with nephropathy whose renal physiology was seen to be clinically impaired occurred relatively early. The major reason was that stromal cells secreting erythropoietin were destroyed earlier.

This shows that there is nocturia and anemia, not simply relying on sleep and drinking less water, usually more attention to rest that can be changed, but also need to be vigilant, timely, systematic, standardized treatment. Once the renal tubules and interstitial lesions are implicated in the glomerulus, the difficulty of the treatment will be greatly increased.

In addition, the diseases caused by the destruction of the physiological function of the renal tubules, the onset is more occult, there is no clinical symptoms or the symptoms are not easily noticeable for a long period of time, and patients often have urine tests or abnormal renal function during physical examination. When the patient presents with clinical symptoms, it may present with non-specific symptoms of primary chronic renal insufficiency, including fatigue, anemia, vomiting, increased nocturia, and sleep disorders. The severity of symptoms depends on the severity of renal failure. In the late stage of the disease, the patient may have edema and hypertension due to glomerulosclerosis.

Most of the patients suffering from renal disease due to the destruction of renal tubular physiological function, the disease development is slow, if found in the early time and remove the cause, the condition can be completely treated; For patients who have suffered from impaired renal function, if reversible factors such as obstruction or infection are detected and treated, the deterioration of renal tubular physiological function can be stopped and the renal function will be improved; By the end of the period (the kidneys have completely deteriorated and the scarred kidneys have formed), the kidneys have undergone irreversible damage, and patients can only maintain their lives by dialysis or kidney transplantation. But now the new natural treatment can help most kidney patients repair the damaged kidney cells and improve their renal function step by step, even the renal failure patients have great opportunity to live the high quality life through the natural treatment.

Kidney disease treatment network research found: The essence of renal tubular lesions is kidney fibrosis. Abnormally increased extracellular matrix insults replace the normal intrinsic cells of the renal tubules and interstitium, affect the normal function of these intrinsic cells, and cause various clinical symptoms such as nocturia and anemia. To this end, after many years of technical research, the Beijing Tongshantang Hospital of Traditional Chinese Medicine has finally developed a systemic natural treatment that blocks kidney fibrosis and repairs the intrinsic cells of the kidney. Traditional Chinese medicine penetration therapy plays a key role in the occurrence of fibrosis in the kidney. After the blockage of renal fibrosis, it also repairs the inherently damaged tubular cells and interstitial cells.

Patients with damaged renal tubular physiology suffer from the interruption of renal fibrosis and repair of damaged cells. The susceptible physique is enhanced, and the symptoms of frequent nocturia, dizziness, and anemia are gradually reduced until completely disappeared! Therefore, as long as we seize the opportunity for better treatment and adhere to standardized treatment, the normal and comfortable life is not far away from us!

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